Antidepressant Comparisons
MAOIs act by inhibiting monoamine oxidase, a complicated enzyme system that metabolizes excess serotonin and epinephrine. It holds the negativity of inducing potential life-threatening problems and thus can not be used in patients with congestive cardiac failure or in those with a history of liver disease. It will be dangerous for those who are hypersensitive to its ingredients. It should be used solely when other available Antidepressant medications fail as treatment choices for depression.
TCAs act mainly by inhibiting the reuptake of both norepinephrine and serotonin. Though the type of side effects experienced by the patient thanks to TCAs or MAOIs are several times similar, the frequency of these side effects is much less in the case of TCAs. So, TCAs get pleasure from a better rate of acceptance by the patients.
The SSRIs act by inhibiting the serotonin reuptake and are thought of the most popular, effective and safe prescription medications. Prozac, a drug of this class, has shown important success in the treatment of depression and prevention of suicide. It exhibits less potential facet effects as compared to TCAs and MAOIs, and is well tolerated.
It should be noted that these three therapeutic teams share the similarity of relieving depressive symptoms in the same amount of your time (1 to four weeks). The SSRIs, because of their profit of safety and tolerability, fancy the stand of 1st-line agents. The TCAs are much cheaper than SSRIs and are preferred by patients who are unresponsive to different Antidepressants.
The SNRIs better serve a patient of depression by aiming to keep each serotonin and norepinephrine at the right level. The drug bupropion (novel Antidepressant) is distinctive in its efficiency to inhibit the reuptake of dopamine, serotonin and norepinephrine.
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